Publications

Publications on Pubmed


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Du Y, Moulick K, Rodina A, Aguirre J, Felts S, Dingledine R, Fu H, Chiosis G.
High-throughput screening fluorescence polarization assay for tumor-specific
Hsp90. J Biomol Screen. 2007 Oct;12(7):915-24. PubMed PMID: 17942784.

Wang X, Yue P, Chan CB, Ye K, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Fu H,
Khuri FR, Sun SY. Inhibition of mammalian target of rapamycin induces
phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation
initiation factor 4E phosphorylation. Mol Cell Biol. 2007 Nov;27(21):7405-13.
PubMed PMID: 17724079; PubMed Central PMCID: PMC2169067.

White LK, Yoon JJ, Lee JK, Sun A, Du Y, Fu H, Snyder JP, Plemper RK.
Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex
activity. Antimicrob Agents Chemother. 2007 Jul;51(7):2293-303. PubMed PMID:
17470652; PubMed Central PMCID: PMC1913224.

Sun SY, Fu H, Khuri FR. Targeting mTOR signaling for lung cancer therapy. J
Thorac Oncol. 2006 Feb;1(2):109-11. Review. PubMed PMID: 17409838.

Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J.
14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in
ZNF198-FGFR1-transformed hematopoietic cells. Blood. 2007 Jul 1;110(1):360-9.
PubMed PMID: 17389761; PubMed Central PMCID: PMC1896121.

Luhn P, Wang H, Marcus AI, Fu H. Identification of FAKTS as a novel
14-3-3-associated nuclear protein. Proteins. 2007 May 1;67(2):479-89. PubMed
PMID: 17256767.

Rong J, Li S, Sheng G, Wu M, Coblitz B, Li M, Fu H, Li XJ. 14-3-3 protein
interacts with Huntingtin-associated protein 1 and regulates its trafficking. J
Biol Chem. 2007 Feb 16;282(7):4748-56. PubMed PMID: 17166838.

Pozdeyev N, Taylor C, Haque R, Chaurasia SS, Visser A, Thazyeen A, Du Y, Fu
H, Weller J, Klein DC, Iuvone PM. Photic regulation of arylalkylamine
N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells. J
Neurosci. 2006 Sep 6;26(36):9153-61. PubMed PMID: 16957072.

Du Y, Masters SC, Khuri FR, Fu H. Monitoring 14-3-3 protein interactions with
a homogeneous fluorescence polarization assay. J Biomol Screen. 2006
Apr;11(3):269-76. PubMed PMID: 16699128.

Porter GW, Khuri FR, Fu H. Dynamic 14-3-3/client protein interactions
integrate survival and apoptotic pathways. Semin Cancer Biol. 2006
Jun;16(3):193-202. Review. PubMed PMID: 16697216.

Wu M, Coblitz B, Shikano S, Long S, Cockrell LM, Fu H, Li M. SWTY--a general
peptide probe for homogeneous solution binding assay of 14-3-3 proteins. Anal
Biochem. 2006 Feb 15;349(2):186-96. PubMed PMID: 16403428.

Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K. Akt phosphorylates acinus and inhibits
its proteolytic cleavage, preventing chromatin condensation. EMBO J. 2005 Oct
19;24(20):3543-54. PubMed PMID: 16177823; PubMed Central PMCID: PMC1276706.

Coblitz B, Shikano S, Wu M, Gabelli SB, Cockrell LM, Spieker M, Hanyu Y, Fu
H, Amzel LM, Li M. C-terminal recognition by 14-3-3 proteins for surface
expression of membrane receptors. J Biol Chem. 2005 Oct 28;280(43):36263-72.
PubMed PMID: 16123035.

Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR. Activation of
Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of
rapamycin inhibition. Cancer Res. 2005 Aug 15;65(16):7052-8. PubMed PMID:
16103051.

Sun SY, Zhou Z, Wang R, Fu H, Khuri FR. The farnesyltransferase inhibitor
Lonafarnib induces growth arrest or apoptosis of human lung cancer cells without
downregulation of Akt. Cancer Biol Ther. 2004 Nov;3(11):1092-8; discussion
1099-1101. PubMed PMID: 15467440.

Ku NO, Fu H, Omary MB. Raf-1 activation disrupts its binding to keratins
during cell stress. J Cell Biol. 2004 Aug 16;166(4):479-85. PubMed PMID:
15314064; PubMed Central PMCID: PMC2172217.

Fujii K, Goldman EH, Park HR, Zhang L, Chen J, Fu H. Negative control of
apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.
Oncogene. 2004 Jun 24;23(29):5099-104. PubMed PMID: 15094778.

Chen J, Williams IR, Kutok JL, Duclos N, Anastasiadou E, Masters SC, Fu H,
Gilliland DG. Positive and negative regulatory roles of the WW-like domain in
TEL-PDGFbetaR transformation. Blood. 2004 Jul 15;104(2):535-42. PubMed PMID:
15054045.
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Subramanian RR, Zhang H, Wang H, Ichijo H, Miyashita T, Fu H. Interaction of
apoptosis signal-regulating kinase 1 with isoforms of 14-3-3 proteins. Exp Cell
Res. 2004 Apr 1;294(2):581-91. PubMed PMID: 15023544.

Goldman EH, Chen L, Fu H. Activation of apoptosis signal-regulating kinase 1
by reactive oxygen species through dephosphorylation at serine 967 and 14-3-3
dissociation. J Biol Chem. 2004 Mar 12;279(11):10442-9. PubMed PMID: 14688258.

Hamaguchi A, Suzuki E, Murayama K, Fujimura T, Hikita T, Iwabuchi K, Handa K,
Withers DA, Masters SC, Fu H, Hakomori S. A sphingosine-dependent protein kinase
that specifically phosphorylates 14-3-3 (SDK1) is identified as the kinase domain
of PKCdelta: a preliminary note. Biochem Biophys Res Commun. 2003 Aug
1;307(3):589-94. PubMed PMID: 12893264.

Hamaguchi A, Suzuki E, Murayama K, Fujimura T, Hikita T, Iwabuchi K, Handa K,
Withers DA, Masters SC, Fu H, Hakomori S. Sphingosine-dependent protein kinase-1,
directed to 14-3-3, is identified as the kinase domain of protein kinase C delta.
J Biol Chem. 2003 Oct 17;278(42):41557-65. PubMed PMID: 12855683.

Truong AB, Masters SC, Yang H, Fu H. Role of the 14-3-3 C-terminal loop in
ligand interaction. Proteins. 2002 Nov 15;49(3):321-5. PubMed PMID: 12360521.
Kahn RA, Fu H, Roy CR. Cellular hijacking: a common strategy for microbial
infection. Trends Biochem Sci. 2002 Jun;27(6):308-14. Review. PubMed PMID:

Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL,

Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S,

Chen J. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1

is important for cancer metabolism. Mol Cell. 2011 Dec 23;44(6):864-77. doi:

10.1016/j.molcel.2011.10.015. PubMed PMID: 22195962; PubMed Central PMCID:

PMC3246218.

Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. 14-3-3 proteins as potential

therapeutic targets. Semin Cell Dev Biol. 2011 Sep;22(7):705-12. doi:

10.1016/j.semcdb.2011.09.012. Review. PubMed PMID: 21983031; PubMed Central

PMCID: PMC3207012.

Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang

B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H. Discovery and structural

characterization of a small molecule 14-3-3 protein-protein interaction

inhibitor. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. doi:

10.1073/pnas.1100012108. PubMed PMID: 21908710; PubMed Central PMCID: PMC3182712.

Li L, Du Y, Chen W, Fu H, Harrison DG. A novel high-throughput screening

assay for discovery of molecules that increase cellular tetrahydrobiopterin. J

Biomol Screen. 2011 Sep;16(8):836-44. doi: 10.1177/1087057111411088. PubMed PMID:

21693765; PubMed Central PMCID: PMC4677475.

Williams DM, Ecroyd H, Goodwin KL, Dai H, Fu H, Woodcock JM, Zhang L, Carver

JA. NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension:

differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.

Biochem J. 2011 Aug 1;437(3):493-503. doi: 10.1042/BJ20102178. PubMed PMID:

21554249.

Cencic R, Desforges M, Hall DR, Kozakov D, Du Y, Min J, Dingledine R, Fu H,

Vajda S, Talbot PJ, Pelletier J. Blocking eIF4E-eIF4G interaction as a strategy

to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. doi:

10.1128/JVI.00078-11. PubMed PMID: 21507972; PubMed Central PMCID: PMC3126520.

Du Y, Nikolovska-Coleska Z, Qui M, Li L, Lewis I, Dingledine R, Stuckey JA,

Krajewski K, Roller PP, Wang S, Fu H. A dual-readout F2 assay that combines

fluorescence resonance energy transfer and fluorescence polarization for

monitoring bimolecular interactions. Assay Drug Dev Technol. 2011

Aug;9(4):382-93. doi: 10.1089/adt.2010.0292. PubMed PMID: 21395401; PubMed

Central PMCID: PMC3148108.

Sun A, Moore TW, Gunther JR, Kim MS, Rhoden E, Du Y, Fu H, Snyder JP,

Katzenellenbogen JA. Discovering small-molecule estrogen receptor α/coactivator

binding inhibitors: high-throughput screening, ligand development, and models for

enhanced potency. ChemMedChem. 2011 Apr 4;6(4):654-66. doi:

10.1002/cmdc.201000507. PubMed PMID: 21365764; PubMed Central PMCID: PMC3177402.

Cencic R, Hall DR, Robert F, Du Y, Min J, Li L, Qui M, Lewis I, Kurtkaya S,

Dingledine R, Fu H, Kozakov D, Vajda S, Pelletier J. Reversing chemoresistance by

small molecule inhibition of the translation initiation complex eIF4F. Proc Natl

Acad Sci U S A. 2011 Jan 18;108(3):1046-51. doi: 10.1073/pnas.1011477108. Erratum

in: Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6689. PubMed PMID: 21191102;

PubMed Central PMCID: PMC3024666.

Qiu X, Du Y, Lou B, Zuo Y, Shao W, Huo Y, Huang J, Yu Y, Zhou B, Du J, Fu H,

Bu X. Synthesis and identification of new 4-arylidene curcumin analogues as

potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med

Chem. 2010 Dec 9;53(23):8260-73. doi: 10.1021/jm1004545. PubMed PMID: 21070043;

PubMed Central PMCID: PMC3990230.

Xu Z, Fulop Z, Wu G, Pone EJ, Zhang J, Mai T, Thomas LM, Al-Qahtani A, White

CA, Park SR, Steinacker P, Li Z, Yates J 3rd, Herron B, Otto M, Zan H, Fu H,

Casali P. 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions

for class switch recombination. Nat Struct Mol Biol. 2010 Sep;17(9):1124-35. doi:

10.1038/nsmb.1884. PubMed PMID: 20729863; PubMed Central PMCID: PMC3645988.

Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta

D, Fu H. Activation of the p38 pathway by a novel monoketone curcumin analog,

EF24, suggests a potential combination strategy. Biochem Pharmacol. 2010 Nov

1;80(9):1309-16. doi: 10.1016/j.bcp.2010.06.048. PubMed PMID: 20615389; PubMed

Central PMCID: PMC3690458.

Ramalingam SS, Harvey RD, Saba N, Owonikoko TK, Kauh J, Shin DM, Sun SY,

Strychor S, Tighiouart M, Egorin MJ, Fu H, Khuri FR. Phase 1 and pharmacokinetic

study of everolimus, a mammalian target of rapamycin inhibitor, in combination

with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer. 2010

Aug 15;116(16):3903-9. doi: 10.1002/cncr.25264. PubMed PMID: 20564143; PubMed

Central PMCID: PMC2940062.

Titus MA, Tan JA, Gregory CW, Ford OH, Subramanian RR, Fu H, Wilson EM,

Mohler JL, French FS. 14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate

Cancer. Clin Cancer Res. 2009 Dec 15;15(24):7571-7581. PubMed PMID: 19996220;

PubMed Central PMCID: PMC2795092.

You J, Dai H, Chen Z, Liu G, He Z, Song F, Yang X, Fu H, Zhang L, Chen X.

Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5

alpha, 6 beta-triol, with new activities from the marine-derived fungus

Trichoderma sp. J Ind Microbiol Biotechnol. 2010 Mar;37(3):245-52. doi:

10.1007/s10295-009-0667-z. PubMed PMID: 19936812.

Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L,

Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Cancer and

virus leads by HTS, chemical design and SEA data mining. Curr Top Med Chem.

2009;9(13):1159-71. Review. PubMed PMID: 19807668; PubMed Central PMCID:

PMC4442615.

Wang R, He H, Sun X, Xu J, Marshall FF, Zhau H, Chung LW, Fu H, He D.

Transcription variants of the prostate-specific PrLZ gene and their interaction

with 14-3-3 proteins. Biochem Biophys Res Commun. 2009 Nov 20;389(3):455-60. doi:

10.1016/j.bbrc.2009.08.165. PubMed PMID: 19732746; PubMed Central PMCID:

PMC3311924.

Du Y, Li Z, Li L, Chen ZG, Sun SY, Chen P, Shin DM, Khuri FR, Fu H. Distinct

growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring

oncogenic signaling pathways in various cancer cells. J Recept Signal Transduct

Res. 2009;29(3-4):182-94. doi: 10.1080/10799890902976933. PubMed PMID: 19604037;

PubMed Central PMCID: PMC3746742.

Jang SW, Liu X, Fu H, Rees H, Yepes M, Levey A, Ye K. Interaction of

Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in

neurons. J Biol Chem. 2009 Sep 4;284(36):24512-25. doi: 10.1074/jbc.M109.026237.

PubMed PMID: 19592491; PubMed Central PMCID: PMC2782043.

Maxwell SA, Li Z, Jaye D, Ballard S, Ferrell J, Fu H. 14-3-3zeta mediates

resistance of diffuse large B cell lymphoma to an anthracycline-based

chemotherapeutic regimen. J Biol Chem. 2009 Aug 14;284(33):22379-89. doi:

10.1074/jbc.M109.022418. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740. Jaya,

David [corrected to Jaye, David]. PubMed PMID: 19525224; PubMed Central PMCID:

PMC2755960.

Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y,

Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel

A, Thomas G. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates

membrane traffic with TRAIL-induced apoptosis. Mol Cell. 2009 May

14;34(4):497-509. doi: 10.1016/j.molcel.2009.04.011. PubMed PMID: 19481529;

PubMed Central PMCID: PMC2744858.

Bialkowska AB, Du Y, Fu H, Yang VW. Identification of novel small-molecule

compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal

cancer cells by high-throughput screening. Mol Cancer Ther. 2009 Mar;8(3):563-70.

doi: 10.1158/1535-7163.MCT-08-0767. PubMed PMID: 19240162; PubMed Central PMCID:

PMC2727710.

Gunther JR, Du Y, Rhoden E, Lewis I, Revennaugh B, Moore TW, Kim SH,

Dingledine R, Fu H, Katzenellenbogen JA. A set of time-resolved fluorescence

resonance energy transfer assays for the discovery of inhibitors of estrogen

receptor-coactivator binding. J Biomol Screen. 2009 Feb;14(2):181-93. doi:

10.1177/1087057108329349. PubMed PMID: 19196699; PubMed Central PMCID:

PMC2731238.

Song X, Coffa S, Fu H, Gurevich VV. How does arrestin assemble MAPKs into a

signaling complex? J Biol Chem. 2009 Jan 2;284(1):685-95. doi:

10.1074/jbc.M806124200. PubMed PMID: 19001375; PubMed Central PMCID: PMC2610502.

Wang X, Hawk N, Yue P, Kauh J, Ramalingam SS, Fu H, Khuri FR, Sun SY.

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling

pathways enhances mTOR inhibitors' anticancer efficacy. Cancer Biol Ther. 2008

Dec;7(12):1952-8. PubMed PMID: 18981735; PubMed Central PMCID: PMC2762753.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY. Enhancing mammalian target of

rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor

inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer Res. 2008

Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522. PubMed PMID: 18794129;

PubMed Central PMCID: PMC2562339.

Ganesh T, Thepchatri P, Li L, Du Y, Fu H, Snyder JP, Sun A. Synthesis and SAR

study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat

shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro

assay. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4982-7. doi:

10.1016/j.bmcl.2008.08.022. PubMed PMID: 18762423; PubMed Central PMCID:

PMC2653417.

Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun

A, Snyder JP, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB

signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel

monoketone analog of curcumin. Mol Pharmacol. 2008 Sep;74(3):654-61. doi:

10.1124/mol.108.046201. PubMed PMID: 18577686; PubMed Central PMCID: PMC2638506.

Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis

G, Dingledine R, Liotta D, Snyder JP, Sun A. Discovery of aminoquinolines as a

new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis,

biology, and molecular modeling. Bioorg Med Chem. 2008 Jul 15;16(14):6903-10.

doi: 10.1016/j.bmc.2008.05.047. PubMed PMID: 18571929; PubMed Central PMCID:

PMC2553564.

Min W, Lin Y, Tang S, Yu L, Zhang H, Wan T, Luhn T, Fu H, Chen H. AIP1

recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK

activation. Circ Res. 2008 Apr 11;102(7):840-8. doi:

10.1161/CIRCRESAHA.107.168153. PubMed PMID: 18292600.

Du Y, Khuri FR, Fu H. A homogenous luminescent proximity assay for 14-3-3

interactions with both phosphorylated and nonphosphorylated client peptides. Curr

Chem Genomics. 2008 Nov 6;2:40-7. doi: 10.2174/1875397300802010040. PubMed PMID:

20161842; PubMed Central PMCID: PMC2803432.

Li Z, Zhao J, Du Y, Park HR, Sun SY, Bernal-Mizrachi L, Aitken A, Khuri FR,

Fu H. Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of

lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008 Jan

8;105(1):162-7. PubMed PMID: 18162532; PubMed Central PMCID: PMC2224179.

Zhou T, Ye L, Bai Y, Sun A, Cox B, Liu D, Li Y, Liotta D, Snyder JP, Fu H,

Huang B. Autophagy and apoptosis in hepatocellular carcinoma induced by

EF25-(GSH)2: a novel curcumin analog. PLoS One. 2014 Sep 30;9(9):e107876. doi:

10.1371/journal.pone.0107876. PubMed PMID: 25268357; PubMed Central PMCID:

PMC4182433.

Tan KL, Ali A, Du Y, Fu H, Jin HX, Chin TM, Khan M, Go ML. Synthesis and

evaluation of bisbenzylidenedioxotetrahydrothiopranones as activators of

endoplasmic reticulum (ER) stress signaling pathways and apoptotic cell death in

acute promyelocytic leukemic cells. J Med Chem. 2014 Jul 24;57(14):5904-18. doi:

10.1021/jm401352a. PubMed PMID: 24960549; PubMed Central PMCID: PMC4216202.

21: Li Z, Park HR, Shi Z, Li Z, Pham CD, Du Y, Khuri FR, Zhang Y, Han Q, Fu H.

Pro-oncogenic function of HIP-55/Drebrin-like (DBNL) through

Ser269/Thr291-phospho-sensor motifs. Oncotarget. 2014 May 30;5(10):3197-209.

PubMed PMID: 24912570; PubMed Central PMCID: PMC4102803.

Kasinski A, Dong X, Khuri FR, Boss J, Fu H. Transcriptional regulation of

YWHAZ, the gene encoding 14-3-3ζ. PLoS One. 2014 Apr 1;9(4):e93480. doi:

10.1371/journal.pone.0093480. PubMed PMID: 24690670; PubMed Central PMCID:

PMC3972145.

Zhu S, Moore TW, Morii N, Howard RB, Culver D, Arrendale RF, Reddy P, Evers

TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM, Snyder JP, Shoji M.

Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous

cell carcinoma xenografts. Curr Cancer Drug Targets. 2014;14(4):380-93. PubMed

PMID: 24628271.

Johns MA, Meyerkord-Belton CL, Du Y, Fu H. The Emory Chemical Biology

Discovery Center: leveraging academic innovation to advance novel targets through

HTS and beyond. Comb Chem High Throughput Screen. 2014 Mar;17(3):290-6. PubMed

PMID: 24409950.

Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC,

Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin

discovered by a generic binding assay. ACS Chem Biol. 2014 Feb 21;9(2):517-25.

doi: 10.1021/cb4007776. PubMed PMID: 24279319; PubMed Central PMCID: PMC3944078.

Xiong F, Jiang M, Huang Z, Chen M, Chen K, Zhou J, Yin L, Tang Y, Wang M, Ye

L, Zhan Z, Duan J, Fu H, Zhang X. A novel herbal formula induces cell cycle

arrest and apoptosis in association with suppressing the PI3K/AKT pathway in

human lung cancer A549 cells. Integr Cancer Ther. 2014 Mar;13(2):152-60. doi:

10.1177/1534735413503544. PubMed PMID: 24105357.

Zheng L, Zhang W, Jiang M, Zhang H, Xiong F, Yu Y, Chen M, Zhou J, Dai X,

Tang Y, Jiang M, Wang M, Cheng G, Duan J, Yu W, Lin B, Fu H, Zhang X. Expression

Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma

H460 Xenografts. Evid Based Complement Alternat Med. 2013;2013:160168. doi:

10.1155/2013/160168. PubMed PMID: 24066008; PubMed Central PMCID: PMC3770002.

Du Y, Fu RW, Lou B, Zhao J, Qui M, Khuri FR, Fu H. A time-resolved

fluorescence resonance energy transfer assay for high-throughput screening of

14-3-3 protein-protein interaction inhibitors. Assay Drug Dev Technol. 2013

Jul;11(6):367-81. doi: 10.1089/adt.2013.507. PubMed PMID: 23906346; PubMed

Central PMCID: PMC3751221.

Liu K, Zhang D, Chojnacki J, Du Y, Fu H, Grant S, Zhang S. Design and

biological characterization of hybrid compounds of curcumin and thalidomide for

multiple myeloma. Org Biomol Chem. 2013 Aug 7;11(29):4757-63. doi:

10.1039/c3ob40595h. PubMed PMID: 23784627.

Ivanov AA, Khuri FR, Fu H. Targeting protein-protein interactions as an

anticancer strategy. Trends Pharmacol Sci. 2013 Jul;34(7):393-400. doi:

10.1016/j.tips.2013.04.007. Review. PubMed PMID: 23725674; PubMed Central PMCID:

PMC3773978.

Jin L, Li D, Lee JS, Elf S, Alesi GN, Fan J, Kang HB, Wang D, Fu H, Taunton

J, Boggon TJ, Tucker M, Gu TL, Chen ZG, Shin DM, Khuri FR, Kang S. p90 RSK2

mediates antianoikis signals by both transcription-dependent and -independent

mechanisms. Mol Cell Biol. 2013 Jul;33(13):2574-85. doi: 10.1128/MCB.01677-12.

PubMed PMID: 23608533; PubMed Central PMCID: PMC3700113.

Li Y, Wang X, Yue P, Tao H, Ramalingam SS, Owonikoko TK, Deng X, Wang Y, Fu

H, Khuri FR, Sun SY. Protein phosphatase 2A and DNA-dependent protein kinase are

involved in mediating rapamycin-induced Akt phosphorylation. J Biol Chem. 2013

May 10;288(19):13215-24. doi: 10.1074/jbc.M113.463679. PubMed PMID: 23536185;

PubMed Central PMCID: PMC3650361.

Puckett MC, Goldman EH, Cockrell LM, Huang B, Kasinski AL, Du Y, Wang CY, Lin

A, Ichijo H, Khuri F, Fu H. Integration of apoptosis signal-regulating kinase

1-mediated stress signaling with the Akt/protein kinase B-IκB kinase cascade. Mol

Cell Biol. 2013 Jun;33(11):2252-9. doi: 10.1128/MCB.00047-13. PubMed PMID:

23530055; PubMed Central PMCID: PMC3648060.

Ramalingam SS, Owonikoko TK, Behera M, Subramanian J, Saba NF, Kono SA, Gal

AA, Sica G, Harvey RD, Chen Z, Klass CM, Shin DM, Fu H, Sun SY, Govindan R, Khuri

FR. Phase II study of docetaxel in combination with everolimus for second- or

third-line therapy of advanced non-small-cell lung cancer. J Thorac Oncol. 2013

Mar;8(3):369-72. doi: 10.1097/JTO.0b013e318282709c. PubMed PMID: 23407561; PubMed

Central PMCID: PMC4126230.

Arkin MR, Glicksman MA, Fu H, Havel JJ, Du Y. Inhibition of Protein-Protein

Interactions: Non-Cellular Assay Formats. 2012 Mar 18 [updated 2012 Oct 1]. In:

Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, Bejcek B,

Glicksman M, Inglese J, Iversen PW, Li Z, McGee J, McManus O, Minor L, Napper A,

Peltier JM, Riss T, Trask OJ Jr., Weidner J, editors. Assay Guidance Manual

[Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for

Advancing Translational Sciences; 2004-. Available from

http://www.ncbi.nlm.nih.gov/books/NBK92000/

PubMed PMID: 22553871.

Li W, Li N, Tang Y, Li B, Liu L, Zhang X, Fu H, Duan JA. Biological activity

evaluation and structure-activity relationships analysis of ferulic acid and

caffeic acid derivatives for anticancer. Bioorg Med Chem Lett. 2012 Oct

1;22(19):6085-8. doi: 10.1016/j.bmcl.2012.08.038. PubMed PMID: 22954735.

Smith SM, Min J, Ganesh T, Diebold B, Kawahara T, Zhu Y, McCoy J, Sun A,

Snyder JP, Fu H, Du Y, Lewis I, Lambeth JD. Ebselen and congeners inhibit NADPH

oxidase 2-dependent superoxide generation by interrupting the binding of

regulatory subunits. Chem Biol. 2012 Jun 22;19(6):752-63. doi:

10.1016/j.chembiol.2012.04.015. PubMed PMID: 22726689; PubMed Central PMCID:

PMC3383625.

Yan YM, Dai HQ, Du Y, Schneider B, Guo H, Li DP, Zhang LX, Fu H, Dong XP,

Cheng YX. Identification of blapsins A and B as potent small-molecule 14-3-3

inhibitors from the insect Blaps japanensis. Bioorg Med Chem Lett. 2012 Jun

15;22(12):4179-81. doi: 10.1016/j.bmcl.2012.04.027. PubMed PMID: 22578460.

Bai Y, Zhou T, Fu H, Sun H, Huang B. 14-3-3 interacts with LKB1 via

recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase

function. FEBS Lett. 2012 Apr 24;586(8):1111-9. doi:

10.1016/j.febslet.2012.03.018. PubMed PMID: 22575644.

Zhu S, Moore TW, Lin X, Morii N, Mancini A, Howard RB, Culver D, Arrendale

RF, Reddy P, Evers TJ, Zhang H, Sica G, Chen ZG, Sun A, Fu H, Khuri FR, Shin DM,

Snyder JP, Shoji M. Synthetic curcumin analog EF31 inhibits the growth of head

and neck squamous cell carcinoma xenografts. Integr Biol (Camb). 2012

Jun;4(6):633-40. doi: 10.1039/c2ib20007d. PubMed PMID: 22532032; PubMed Central

PMCID: PMC3734847.

Ramachandiran S, Cain J, Liao A, He Y, Guo X, Boise LH, Fu H, Ratner L,

Khoury HJ, Bernal-Mizrachi L. The Smac mimetic RMT5265.2HCL induces apoptosis in

EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the

mitochondrial release of cytochrome C and Smac. Leuk Res. 2012 Jun;36(6):784-90.

doi: 10.1016/j.leukres.2011.12.024. PubMed PMID: 22325366; PubMed Central PMCID:

PMC3331941.

Andersen SD, Keijzers G, Rampakakis E, Engels K, Luhn P, El-Shemerly M,

Nielsen FC, Du Y, May A, Bohr VA, Ferrari S, Zannis-Hadjopoulos M, Fu H,

Rasmussen LJ. 14-3-3 checkpoint regulatory proteins interact specifically with

DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA

Repair (Amst). 2012 Mar 1;11(3):267-77. doi: 10.1016/j.dnarep.2011.11.007. PubMed

PMID: 22222486; PubMed Central PMCID: PMC4586177.

Qi Q, He K, Yoo MH, Chan CB, Liu X, Zhang Z, Olson JJ, Xiao G, Wang L, Mao H,

Fu H, Tao H, Ramalingam SS, Sun SY, Mischel PS, Ye K. Acridine yellow G blocks

glioblastoma growth via dual inhibition of epidermal growth factor receptor and

protein kinase C kinases. J Biol Chem. 2012 Feb 24;287(9):6113-27. doi:

10.1074/jbc.M111.293605. PubMed PMID: 22215664; PubMed Central PMCID: PMC3307261.

AKT1, LKB1, and YAP1 revealed as MYC interactors with NanoLuc-based protein-fragment complementation assay.
Mo XL, Qi Q, Ivanov AA, Niu Q, Luo Y, Havel J, Goetze R, Bell S, Moreno CS, Cooper LA, Johns MA, Khuri FR, Du Y, Fu H.
Mol Pharmacol. 2017 Jan 13. pii: mol.116.107623. doi: 10.1124/mol.116.107623. [Epub ahead of print]
PMID: 28087810

2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.
Sun L, Liu X, Fu H, Zhou W, Zhong D.
PLoS One. 2016 Dec 29;11(12):e0168793. doi: 10.1371/journal.pone.0168793.
PMID: 28033353

Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X.
Cell Chem Biol. 2016 Jul 21;23(7):769-81. doi: 10.1016/j.chembiol.2016.06.006.
PMID: 27427228

Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales

SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A,

Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X. Structural

Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell

Chem Biol. 2016 Jul 21;23(7):769-81. doi: 10.1016/j.chembiol.2016.06.006. PubMed

PMID: 27427228; PubMed Central PMCID: PMC4958579.

Mo XL, Fu H. BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer

Platform to Monitor Protein-Protein Interactions in Live Cells. Methods Mol Biol.

2016;1439:263-71. doi: 10.1007/978-1-4939-3673-1_17. PubMed PMID: 27317001.

Chen M, Guo Y, Zhao R, Wang X, Jiang M, Fu H, Zhang X. Ophiopogonin B induces

apoptosis, mitotic catastrophe and autophagy in A549 cells. Int J Oncol. 2016

Jul;49(1):316-24. doi: 10.3892/ijo.2016.3514. PubMed PMID: 27175570.

Konen J, Wilkinson S, Lee B, Fu H, Zhou W, Jiang Y, Marcus AI. LKB1

kinase-dependent and -independent defects disrupt polarity and adhesion signaling

to drive collagen remodeling during invasion. Mol Biol Cell. 2016 Apr

1;27(7):1069-84. doi: 10.1091/mbc.E15-08-0569. PubMed PMID: 26864623; PubMed

Central PMCID: PMC4814216.

6: Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA,

Vertino PM, Fu H, Cheng X. Characterization of a Linked Jumonji Domain of the

KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. J Biol Chem. 2016 Feb

5;291(6):2631-46. doi: 10.1074/jbc.M115.698449. PubMed PMID: 26645689; PubMed

Central PMCID: PMC4742734.

7: Mo XL, Luo Y, Ivanov AA, Su R, Havel JJ, Li Z, Khuri FR, Du Y, Fu H. Enabling

systematic interrogation of protein-protein interactions in live cells with a

versatile ultra-high-throughput biosensor platform. J Mol Cell Biol. 2016

Jun;8(3):271-81. doi: 10.1093/jmcb/mjv064. PubMed PMID: 26578655; PubMed Central

PMCID: PMC4937889.

8: Liu F, Jin R, Liu X, Huang H, Wilkinson SC, Zhong D, Khuri FR, Fu H, Marcus A,

He Y, Zhou W. LKB1 promotes cell survival by modulating TIF-IA-mediated

pre-ribosomal RNA synthesis under uridine downregulated conditions. Oncotarget.

2016 Jan 19;7(3):2519-31. doi: 10.18632/oncotarget.6224. PubMed PMID: 26506235;

PubMed Central PMCID: PMC4823052.

9: Webber PJ, Park C, Qui M, Ramalingam SS, Khuri FR, Fu H, Du Y. Combination of

heat shock protein 90 and focal adhesion kinase inhibitors synergistically

inhibits the growth of non-small cell lung cancer cells. Oncoscience. 2015 Sep

15;2(9):765-76. PubMed PMID: 26501082; PubMed Central PMCID: PMC4606010.

10: Fu H, Napper AD. Interview with Haian Fu, PhD. Assay Drug Dev Technol. 2015

Jun;13(5):249-53. doi: 10.1089/adt.2015.29004.hfu. PubMed PMID: 26168060; PubMed

Central PMCID: PMC4507085.

11: Zhao R, Chen M, Jiang Z, Zhao F, Xi B, Zhang X, Fu H, Zhou K. Platycodin-D

Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK

Signaling Pathways. J Cancer. 2015 May 23;6(7):623-31. doi: 10.7150/jca.11291.

PubMed PMID: 26078792; PubMed Central PMCID: PMC4466411.

12: Feng X, Li Z, Du Y, Fu H, Klein JD, Cai H, Sands JM, Chen G. Downregulation

of urea transporter UT-A1 activity by 14-3-3 protein. Am J Physiol Renal Physiol.

2015 Jul 1;309(1):F71-8. doi: 10.1152/ajprenal.00546.2014. PubMed PMID: 25995111;

PubMed Central PMCID: PMC4490382.

13: Marin M, Du Y, Giroud C, Kim JH, Qui M, Fu H, Melikyan GB. High-Throughput

HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors. Assay Drug Dev

Technol. 2015 Apr;13(3):155-66. doi: 10.1089/adt.2015.639. PubMed PMID: 25871547;

PubMed Central PMCID: PMC4410757.

14: Yang Q, Li W, She H, Dou J, Duong DM, Du Y, Yang SH, Seyfried NT, Fu H, Gao

G, Mao Z. Stress induces p38 MAPK-mediated phosphorylation and inhibition of

Drosha-dependent cell survival. Mol Cell. 2015 Feb 19;57(4):721-34. doi:

10.1016/j.molcel.2015.01.004. PubMed PMID: 25699712; PubMed Central PMCID:

PMC4502444.

15: Owonikoko TK, Ramalingam SS, Miller DL, Force SD, Sica GL, Mendel J, Chen Z,

Rogatko A, Tighiouart M, Harvey RD, Kim S, Saba NF, Pickens A, Behera M, Fu RW,

Rossi MR, Auffermann WF, Torres WE, Bechara R, Deng X, Sun SY, Fu H, Gal AA,

Khuri FR. A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical

Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clin Cancer Res.

2015 Apr 15;21(8):1859-68. doi: 10.1158/1078-0432.CCR-14-1998. PubMed PMID:

25673697; PubMed Central PMCID: PMC4401630.

16: Zhu J, Chen M, Chen N, Ma A, Zhu C, Zhao R, Jiang M, Zhou J, Ye L, Fu H,

Zhang X. Glycyrrhetinic acid induces G1‚Äëphase cell cycle arrest in human

non‚Äësmall cell lung cancer cells through endoplasmic reticulum stress pathway.

Int J Oncol. 2015 Mar;46(3):981-8. doi: 10.3892/ijo.2015.2819. PubMed PMID:

25573651; PubMed Central PMCID: PMC4324580.

17: Shi Z, Park HR, Du Y, Li Z, Cheng K, Sun SY, Li Z, Fu H, Khuri FR. Cables1

complex couples survival signaling to the cell death machinery. Cancer Res. 2015

Jan 1;75(1):147-58. doi: 10.1158/0008-5472.CAN-14-0036. PubMed PMID: 25361894;

PubMed Central PMCID: PMC4617824.

18: Ramachandiran S, Adon A, Guo X, Wang Y, Wang H, Chen Z, Kowalski J, Sunay UR,

Young AN, Brown T, Mar JC, Du Y, Fu H, Mann KP, Natkunam Y, Boise LH, Saavedra

HI, Lossos IS, Bernal-Mizrachi L. Chromosome instability in diffuse large B cell

lymphomas is suppressed by activation of the noncanonical NF-κB pathway. Int J

Cancer. 2015 May 15;136(10):2341-51. doi: 10.1002/ijc.29301. PubMed PMID:

25359525; PubMed Central PMCID: PMC4880031.

C.L. Meyerkord, H. Fu (Eds.) Protein-Protein Interactions: Methods and Applications. Methods in Molecular Biology, Vol. 1278 (2015)

Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL,

Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S,

Chen J. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1

is important for cancer metabolism. Mol Cell. 2011 Dec 23;44(6):864-77. doi:

10.1016/j.molcel.2011.10.015. PubMed PMID: 22195962; PubMed Central PMCID:

PMC3246218.

Zhao J, Meyerkord CL, Du Y, Khuri FR, Fu H. 14-3-3 proteins as potential

therapeutic targets. Semin Cell Dev Biol. 2011 Sep;22(7):705-12. doi:

10.1016/j.semcdb.2011.09.012. Review. PubMed PMID: 21983031; PubMed Central

PMCID: PMC3207012.

Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang

B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H. Discovery and structural

characterization of a small molecule 14-3-3 protein-protein interaction

inhibitor. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6. doi:

10.1073/pnas.1100012108. PubMed PMID: 21908710; PubMed Central PMCID: PMC3182712.

Li L, Du Y, Chen W, Fu H, Harrison DG. A novel high-throughput screening

assay for discovery of molecules that increase cellular tetrahydrobiopterin. J

Biomol Screen. 2011 Sep;16(8):836-44. doi: 10.1177/1087057111411088. PubMed PMID:

21693765; PubMed Central PMCID: PMC4677475.

Williams DM, Ecroyd H, Goodwin KL, Dai H, Fu H, Woodcock JM, Zhang L, Carver

JA. NMR spectroscopy of 14-3-3ζ reveals a flexible C-terminal extension:

differentiation of the chaperone and phosphoserine-binding activities of 14-3-3ζ.

Biochem J. 2011 Aug 1;437(3):493-503. doi: 10.1042/BJ20102178. PubMed PMID:

21554249.

Cencic R, Desforges M, Hall DR, Kozakov D, Du Y, Min J, Dingledine R, Fu H,

Vajda S, Talbot PJ, Pelletier J. Blocking eIF4E-eIF4G interaction as a strategy

to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. doi:

10.1128/JVI.00078-11. PubMed PMID: 21507972; PubMed Central PMCID: PMC3126520.

Du Y, Nikolovska-Coleska Z, Qui M, Li L, Lewis I, Dingledine R, Stuckey JA,

Krajewski K, Roller PP, Wang S, Fu H. A dual-readout F2 assay that combines

fluorescence resonance energy transfer and fluorescence polarization for

monitoring bimolecular interactions. Assay Drug Dev Technol. 2011

Aug;9(4):382-93. doi: 10.1089/adt.2010.0292. PubMed PMID: 21395401; PubMed

Central PMCID: PMC3148108.

Sun A, Moore TW, Gunther JR, Kim MS, Rhoden E, Du Y, Fu H, Snyder JP,

Katzenellenbogen JA. Discovering small-molecule estrogen receptor α/coactivator

binding inhibitors: high-throughput screening, ligand development, and models for

enhanced potency. ChemMedChem. 2011 Apr 4;6(4):654-66. doi:

10.1002/cmdc.201000507. PubMed PMID: 21365764; PubMed Central PMCID: PMC3177402.

Cencic R, Hall DR, Robert F, Du Y, Min J, Li L, Qui M, Lewis I, Kurtkaya S,

Dingledine R, Fu H, Kozakov D, Vajda S, Pelletier J. Reversing chemoresistance by

small molecule inhibition of the translation initiation complex eIF4F. Proc Natl

Acad Sci U S A. 2011 Jan 18;108(3):1046-51. doi: 10.1073/pnas.1011477108. Erratum

in: Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6689. PubMed PMID: 21191102;

PubMed Central PMCID: PMC3024666.

Qiu X, Du Y, Lou B, Zuo Y, Shao W, Huo Y, Huang J, Yu Y, Zhou B, Du J, Fu H,

Bu X. Synthesis and identification of new 4-arylidene curcumin analogues as

potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med

Chem. 2010 Dec 9;53(23):8260-73. doi: 10.1021/jm1004545. PubMed PMID: 21070043;

PubMed Central PMCID: PMC3990230.

Xu Z, Fulop Z, Wu G, Pone EJ, Zhang J, Mai T, Thomas LM, Al-Qahtani A, White

CA, Park SR, Steinacker P, Li Z, Yates J 3rd, Herron B, Otto M, Zan H, Fu H,

Casali P. 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions

for class switch recombination. Nat Struct Mol Biol. 2010 Sep;17(9):1124-35. doi:

10.1038/nsmb.1884. PubMed PMID: 20729863; PubMed Central PMCID: PMC3645988.

Thomas SL, Zhao J, Li Z, Lou B, Du Y, Purcell J, Snyder JP, Khuri FR, Liotta

D, Fu H. Activation of the p38 pathway by a novel monoketone curcumin analog,

EF24, suggests a potential combination strategy. Biochem Pharmacol. 2010 Nov

1;80(9):1309-16. doi: 10.1016/j.bcp.2010.06.048. PubMed PMID: 20615389; PubMed

Central PMCID: PMC3690458.

Ramalingam SS, Harvey RD, Saba N, Owonikoko TK, Kauh J, Shin DM, Sun SY,

Strychor S, Tighiouart M, Egorin MJ, Fu H, Khuri FR. Phase 1 and pharmacokinetic

study of everolimus, a mammalian target of rapamycin inhibitor, in combination

with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer. 2010

Aug 15;116(16):3903-9. doi: 10.1002/cncr.25264. PubMed PMID: 20564143; PubMed

Central PMCID: PMC2940062.

Titus MA, Tan JA, Gregory CW, Ford OH, Subramanian RR, Fu H, Wilson EM,

Mohler JL, French FS. 14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate

Cancer. Clin Cancer Res. 2009 Dec 15;15(24):7571-7581. PubMed PMID: 19996220;

PubMed Central PMCID: PMC2795092.

You J, Dai H, Chen Z, Liu G, He Z, Song F, Yang X, Fu H, Zhang L, Chen X.

Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5

alpha, 6 beta-triol, with new activities from the marine-derived fungus

Trichoderma sp. J Ind Microbiol Biotechnol. 2010 Mar;37(3):245-52. doi:

10.1007/s10295-009-0667-z. PubMed PMID: 19936812.

Thepchatri P, Min J, Ganesh T, Du Y, Lewis I, Kurtkaya S, Prussia A, Li L,

Sneed B, Plemper RK, Fu H, Liotta DC, Snyder JP, Dingledine R, Sun A. Cancer and

virus leads by HTS, chemical design and SEA data mining. Curr Top Med Chem.

2009;9(13):1159-71. Review. PubMed PMID: 19807668; PubMed Central PMCID:

PMC4442615.

Wang R, He H, Sun X, Xu J, Marshall FF, Zhau H, Chung LW, Fu H, He D.

Transcription variants of the prostate-specific PrLZ gene and their interaction

with 14-3-3 proteins. Biochem Biophys Res Commun. 2009 Nov 20;389(3):455-60. doi:

10.1016/j.bbrc.2009.08.165. PubMed PMID: 19732746; PubMed Central PMCID:

PMC3311924.

Du Y, Li Z, Li L, Chen ZG, Sun SY, Chen P, Shin DM, Khuri FR, Fu H. Distinct

growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring

oncogenic signaling pathways in various cancer cells. J Recept Signal Transduct

Res. 2009;29(3-4):182-94. doi: 10.1080/10799890902976933. PubMed PMID: 19604037;

PubMed Central PMCID: PMC3746742.

Jang SW, Liu X, Fu H, Rees H, Yepes M, Levey A, Ye K. Interaction of

Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in

neurons. J Biol Chem. 2009 Sep 4;284(36):24512-25. doi: 10.1074/jbc.M109.026237.

PubMed PMID: 19592491; PubMed Central PMCID: PMC2782043.

Maxwell SA, Li Z, Jaye D, Ballard S, Ferrell J, Fu H. 14-3-3zeta mediates

resistance of diffuse large B cell lymphoma to an anthracycline-based

chemotherapeutic regimen. J Biol Chem. 2009 Aug 14;284(33):22379-89. doi:

10.1074/jbc.M109.022418. Erratum in: J Biol Chem. 2010 Dec 3;285(49):38740. Jaya,

David [corrected to Jaye, David]. PubMed PMID: 19525224; PubMed Central PMCID:

PMC2755960.

Aslan JE, You H, Williamson DM, Endig J, Youker RT, Thomas L, Shu H, Du Y,

Milewski RL, Brush MH, Possemato A, Sprott K, Fu H, Greis KD, Runckel DN, Vogel

A, Thomas G. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates

membrane traffic with TRAIL-induced apoptosis. Mol Cell. 2009 May

14;34(4):497-509. doi: 10.1016/j.molcel.2009.04.011. PubMed PMID: 19481529;

PubMed Central PMCID: PMC2744858.

Bialkowska AB, Du Y, Fu H, Yang VW. Identification of novel small-molecule

compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal

cancer cells by high-throughput screening. Mol Cancer Ther. 2009 Mar;8(3):563-70.

doi: 10.1158/1535-7163.MCT-08-0767. PubMed PMID: 19240162; PubMed Central PMCID:

PMC2727710.

Gunther JR, Du Y, Rhoden E, Lewis I, Revennaugh B, Moore TW, Kim SH,

Dingledine R, Fu H, Katzenellenbogen JA. A set of time-resolved fluorescence

resonance energy transfer assays for the discovery of inhibitors of estrogen

receptor-coactivator binding. J Biomol Screen. 2009 Feb;14(2):181-93. doi:

10.1177/1087057108329349. PubMed PMID: 19196699; PubMed Central PMCID:

PMC2731238.

Song X, Coffa S, Fu H, Gurevich VV. How does arrestin assemble MAPKs into a

signaling complex? J Biol Chem. 2009 Jan 2;284(1):685-95. doi:

10.1074/jbc.M806124200. PubMed PMID: 19001375; PubMed Central PMCID: PMC2610502.

Wang X, Hawk N, Yue P, Kauh J, Ramalingam SS, Fu H, Khuri FR, Sun SY.

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling

pathways enhances mTOR inhibitors' anticancer efficacy. Cancer Biol Ther. 2008

Dec;7(12):1952-8. PubMed PMID: 18981735; PubMed Central PMCID: PMC2762753.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY. Enhancing mammalian target of

rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor

inhibition-initiated, mTOR/rictor-independent Akt activation. Cancer Res. 2008

Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522. PubMed PMID: 18794129;

PubMed Central PMCID: PMC2562339.

Ganesh T, Thepchatri P, Li L, Du Y, Fu H, Snyder JP, Sun A. Synthesis and SAR

study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat

shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro

assay. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4982-7. doi:

10.1016/j.bmcl.2008.08.022. PubMed PMID: 18762423; PubMed Central PMCID:

PMC2653417.

Kasinski AL, Du Y, Thomas SL, Zhao J, Sun SY, Khuri FR, Wang CY, Shoji M, Sun

A, Snyder JP, Liotta D, Fu H. Inhibition of IkappaB kinase-nuclear factor-kappaB

signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel

monoketone analog of curcumin. Mol Pharmacol. 2008 Sep;74(3):654-61. doi:

10.1124/mol.108.046201. PubMed PMID: 18577686; PubMed Central PMCID: PMC2638506.

Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis

G, Dingledine R, Liotta D, Snyder JP, Sun A. Discovery of aminoquinolines as a

new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis,

biology, and molecular modeling. Bioorg Med Chem. 2008 Jul 15;16(14):6903-10.

doi: 10.1016/j.bmc.2008.05.047. PubMed PMID: 18571929; PubMed Central PMCID:

PMC2553564.

Min W, Lin Y, Tang S, Yu L, Zhang H, Wan T, Luhn T, Fu H, Chen H. AIP1

recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK

activation. Circ Res. 2008 Apr 11;102(7):840-8. doi:

10.1161/CIRCRESAHA.107.168153. PubMed PMID: 18292600.

Du Y, Khuri FR, Fu H. A homogenous luminescent proximity assay for 14-3-3

interactions with both phosphorylated and nonphosphorylated client peptides. Curr

Chem Genomics. 2008 Nov 6;2:40-7. doi: 10.2174/1875397300802010040. PubMed PMID:

20161842; PubMed Central PMCID: PMC2803432.

Li Z, Zhao J, Du Y, Park HR, Sun SY, Bernal-Mizrachi L, Aitken A, Khuri FR,

Fu H. Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of

lung cancer cells through anoikis activation. Proc Natl Acad Sci U S A. 2008 Jan

8;105(1):162-7. PubMed PMID: 18162532; PubMed Central PMCID: PMC2224179.