Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.  
Lee C-M, Tripathi S and Morgan ET
Free Radic. Biol. Med 2017 E-pub April 17, 2017.  Doi 10.1016/j.freeradbiomed.2017.04.015

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. 
Mimche PN, Brady LM, Bray CF, Thapa M, McDermott CD, King TP, Quicke K, Lee CM, Mimche SM, Grakoui A Morgan ET and Lamb TJ 
Hepatology (2015) 62: 900-914 E-pub Mar 17, 2015 doi: 10.1002/hep.27792. 
PMCID: 5459176; PMID 25784101.

Selective effects of a therapeutic protein targeting tumor necrosis factor-alpha on cytochrome P450 regulation during infectious colitis: Implications for disease-dependent drug-drug interactions. 
Nyagode BA, Janhangardi R, Merrell MD, Tansey M and Morgan ET 
Pharmacol Res Perspect (2014) 2(1):e00027. 
PMC3972819; PMID24707356.

Selective and cytokine-dependent regulation of hepatic transporters and bile acid homeostasis during infectious colitis in mice.   
Merrell MD, Nyagode BA, Clarke JD, Cherrington NJ and Morgan ET 
Drug Metab Dispos (2014) 42: 596-602 E-pub Dec 30, 2013, doi:10.1124/dmd.113.055525.  
PMC396589; PMID24378326.

Altered inflammatory responses to Citrobacter rodentium infection, but not to bacterial lipopolysaccharide, in mice lacking the Cyp4a10 and Cyp4a14 genes.  Nyagode BA, Williams I and Morgan ET 
Inflammation (2014), 37:893-907 E-pub Jan 11, 2014. Doi 10.1007/s10753-013-9809-6. 
PMC4035451; PMID24413902. Article PDF

Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are down-regulated in a Th2 environment during Schistosoma mansoni infection. 
Mimche SM, Nyagode BA, Merrell MD, Lee C-M, Prasanphanich NS, Cummings RD and Morgan ET (2014)  Drug Metab Dispos  42: 134-40.  E-pub October 25, 2013,  doi:10.1124/dmd.113.054957  PMC3876789; PMID24163175.

Nitric oxide and interleukin-1b stimulate the proteasome-independent degradation of the retinoic acid hydroxylase CYP2C22 in primary rat hepatocytes. 
Lee C-M, Lee B-M, Arnold SL, Isoherranen N and Morgan, ET (2013) 
J. Pharmacol. Exp. Ther. 
 348: 141-152.  E-pub October 21, doi:10.1124/jpet.113.209841 
PMC3868880; PMID24144795.

Selective Modulation of Hepatic Cytochrome P450 and Flavin Monooxygenase 3 Expression during Citrobacter rodentium Infection in Severe Combined Immune-Deficient Mice
Nyagode BA, Watkins WJ, Kinloch RD and Morgan ET (2012)   
Drug Metab Dispos  40: 1894-1899  
PMC3463824; PMID22745333.

Nitric oxide-dependent CYP2B1 degradation is potentiated by a cytokine-regulated pathway and utilizes the immunoproteasome subunit LMP2.
Sun H, Lee C-M, Tripathi S, Kim K-B and Morgan ET (2012)   
Biochem. J445: 377-382.  e-pub May 22. Doi 10.1042/BJ20120820. 
PMC3557507; PMID22612225. Article PDF

Selective Role for Tumor Necrosis Factor-a, but Not Interleukin-1 or Kupffer Cells, in Down-Regulation of CYP3A11 and CYP3A25 in Livers of Mice Infected with a Noninvasive Intestinal Pathogen.
Kinloch RD, Lee C-M, van Rooijen N and Morgan ET   
Biochem. Pharmacol. (2011) 82: 312-321. e-pub June 23, 2011
PMC3124565; PMID21570957.

Metabolism and action of proteasome inhibitors in primary human hepatocytes.
Lee CM, Kumar V, Riley RI, Morgan ET.
Drug Metab Dispos. 2010 Dec;38(12):2166-72. Epub 2010 Sep 13.
PMID: 20837660

Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6- and interferon-{gamma}-null mice.
Nyagode BA, Lee CM, Morgan ET.
J Pharmacol Exp Ther. 2010 Nov;335(2):480-8. Epub 2010 Aug 18.
PMID: 20719939

Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures.
Lee CM, Pohl J, Morgan ET.
Drug Metab Dispos. 2009 Apr;37(4):865-72. Epub 2009 Jan 26.
PMID: 19171675

Hepatic flavin-containing monooxygenase gene regulation in different mouse inflammation models.
Zhang J, Chaluvadi MR, Reddy R, Motika MS, Richardson TA, Cashman JR, Morgan ET.
Drug Metab Dispos. 2009 Mar;37(3):462-8. Epub 2008 Dec 16.
PMID: 19088265

TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease.
Chaluvadi MR, Nyagode BA, Kinloch RD, Morgan ET.
Biochem Pharmacol. 2009 Feb 1;77(3):464-71. Epub 2008 Nov 6.
PMID: 19027721

Regulation of hepatic cytochrome P450 expression in mice with intestinal or systemic infections of citrobacter rodentium.
Chaluvadi MR, Kinloch RD, Nyagode BA, Richardson TA, Raynor MJ, Sherman M, Antonovic L, Strobel HW, Dillehay DL, Morgan ET.
Drug Metab Dispos. 2009 Feb;37(2):366-74. Epub 2008 Oct 29.
PMID: 18971315

Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis.
Chen C, Shah YM, Morimura K, Krausz KW, Miyazaki M, Richardson TA, Morgan ET, Ntambi JM, Idle JR, Gonzalez FJ.
Cell Metab. 2008 Feb;7(2):135-47.
PMID: 18249173

Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer.
Morgan ET, Goralski KB, Piquette-Miller M, Renton KW, Robertson GR, Chaluvadi MR, Charles KA, Clarke SJ, Kacevska M, Liddle C, Richardson TA, Sharma R, Sinal CJ.
Drug Metab Dispos. 2008 Feb;36(2):205-16.
MID: 18218849

Roles of nitric oxide in inflammatory downregulation of human cytochromes P450.
Aitken AE, Lee CM, Morgan ET.
Free Radic Biol Med. 2008 Mar 15;44(6):1161-8. Epub 2007 Dec 23.
PMID: 18206661

Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins.
Lee CM, Kim BY, Li L, Morgan ET.
J Biol Chem. 2008 Jan 11;283(2):889-98. Epub 2007 Nov 9.
PMID: 17993647

Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.
Aitken AE, Morgan ET.
Drug Metab Dispos. 2007 Sep;35(9):1687-93. Epub 2007 Jun 18.
PMID: 17576808

Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.
Kalsotra A, Anakk S, Brommer CL, Kikuta Y, Morgan ET, Strobel HW.
Arch Biochem Biophys. 2007 May 1;461(1):104-12. Epub 2007 Mar 15.
PMID: 17418803

Regulation of drug-metabolizing enzymes and transporters in inflammation.
Aitken AE, Richardson TA, Morgan ET.
Annu Rev Pharmacol Toxicol. 2006;46:123-49. Review.
PMID: 16402901

Hepatic and renal cytochrome p450 gene regulation during citrobacter rodentium infection in wild-type and toll-like receptor 4 mutant mice.
Richardson TA, Sherman M, Antonovic L, Kardar SS, Strobel HW, Kalman D, Morgan ET.
Drug Metab Dispos. 2006 Mar;34(3):354-60. Epub 2005 Dec 8.
PMID: 16339354

Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney.
Richardson TA, Sherman M, Kalman D, Morgan ET.
Drug Metab Dispos. 2006 Mar;34(3):351-3. Epub 2005 Dec 8.
PMID: 16339353

Hepatic cytochrome P450 gene regulation during endotoxin-induced inflammation in nuclear receptor knockout mice.
Richardson TA, Morgan ET.
J Pharmacol Exp Ther. 2005 Aug;314(2):703-9. Epub 2005 Apr 28.
PMID: 15860574

A role for one or more p450 enzymes in the response to sepsis.
Morgan ET.
Crit Care Med. 2005 Jan;33(1):268-9. No abstract available.
PMID: 15644701

Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.
Riddick DS, Lee C, Bhathena A, Timsit YE, Cheng PY, Morgan ET, Prough RA, Ripp SL, Miller KK, Jahan A, Chiang JY.
Drug Metab Dispos. 2004 Apr;32(4):367-75. Review.
PMID: 15039287

Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B(4) omega-hydroxylases in rat liver and kidney.
Kalsotra A, Cui X, Antonovic L, Robida AM, Morgan ET, Strobel HW.
FEBS Lett. 2003 Dec 4;555(2):236-42.
PMID: 14644421

Rapid transcriptional suppression of rat cytochrome P450 genes by endotoxin treatment and its inhibition by curcumin.
Cheng PY, Wang M, Morgan ET.
J Pharmacol Exp Ther. 2003 Dec;307(3):1205-12. Epub 2003 Oct 13.
PMID: 14557382

Mechanisms of cytochrome P450 regulation by inflammatory mediators.
Morgan ET, Li-Masters T, Cheng PY.
Toxicology. 2002 Dec 27;181-182:207-10. Review.
PMID: 12505312

Down-regulation of phenobarbital-induced cytochrome P4502B mRNAs and proteins by endotoxin in mice: independence from nitric oxide production by inducible nitric oxide synthase.
Li-Masters T, Morgan ET.
Biochem Pharmacol. 2002 Dec 15;64(12):1703-11.
PMID: 1244585

Morgan ET (2012) Editorial. Drug Metab. Dispos40: 413.  PMID22337621

Morgan ET, Lee C-M and Nyagode BA (2012) Regulation of Drug Metabolizing Enzymes in Infection, Inflammation and Cancer.  In Encyclopedia of Drug Metabolism and Interactions, vol. 8 (AV Lyubimov, ed.).  Wiley DOI: 10.1002/9780470921920.edm089

Morgan ET (2017) Regulation of Drug Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses.  In Drug Metabolism in Diseases (W. Xie, ed.) Academic Press, Elsevier, Amsterdam. ISBN: 978-0-12-802949-7

Yu A-M, Ingelman-Sundberg M, Cherrington N, Aleksunes L, Zanger UM, Xie W, Jeong H, Morgan E, Turnbaugh PJ, Klaassen CD, Redinbo M, Hao P,  Waxman DJ, Wang L and Zhong, X-B. (2017).  A meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO).  Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases. Acta Pharmaceutica Sinica part B,  in press.