Publications

1. Feng, Y., and J. S. Han.  Central depression effect of U50488H: a highly selective Kappa opioid agonist. Sheng Li Hsueh Pao  (1987) 39:305-9 (English abstract).

2. Cavener, D. R., Y. Feng, B. Foster, P. Krasney, M. Murtha, C. Schonbuam, and X. Xiao.  The YYRR box: A conserved dipyrimidine-dipurine sequence element in Drosophila and other eukaryotes. Nucl. Acids Res. (1988)  16:3375-3390

3. Singleton, C. K., S. S. Manning, and Y. Feng.  Effect of protein synthesis inhibition on gene expression during early development of Dictyostelium discoideum. Mol. Cell. Biol. (1988)  8:10-16

4. Feng Y., Krasney P, Schiff N, and Cavener DR.  Organ-specific patterns of gene expression in the reproductive tract of Drosophila are regulated by the sex-determinationgenes. Dev. Biol. (1991) 146:451-460

5. Feng Y., Gunter L, Organ E, and Cavener DR. Translation initiation in Drosophila is reduced by mutation upstream of the AUG initiation codon.  Mol. Cell. Biol. (1991) 11:2149-2153

6. Schiff, N., Y. Feng, J. Quine, P. Krasney, and D. Cavener. Evolution of the expression of the Gld gene in the reproductive tract of Drosophila. Mol. Bio. Evol.  (1992) 9:1029-1049

7. Feng Y., Lakkis L, Devys D, and  Warren ST. Quantitative comparison of FMR1 gene expression in normal and premutation alleles. Am. J. Hum. Genet.  (1995) 56:106-113

8. Feng Y.,  Zhang F,  Lokey L, Chastain J,  Lakkis L,  Eberhart D, and  Warren ST. Translational suppression by trinucleotide repeat expansion at FMR1. Science  (1995) 268:731-734

9. Eberhart  DE,  Malter HE,  Feng Y, and Warren ST. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals. Hum. Mol. Genet.  (1996) 5: 1083-1091

10. Lachiewicz AM, Spiridigliozzi GA,  McConkie-Rosell A,  Burgess D,  Feng Y, Warren ST,  Tarleton J. A fragile X male with a broad smear on Southern blot analysis representing 100 to 500 CGG repeats and no methylation at the EagI site of the FMR-1 gene. Am. J. Med. Genet. (1996) 64: 278-282

11. Feng, Y., Gutekunst CA,  Eberhart DE,  Yi H, Warren ST, and Hersch SM. Fragile X mental retardation protein:  nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J. Neurosci. (1997) 17: 1539-1547

12. Feng, Y., Absher D, Eberhart D, Brown V, Malter HE, and Warren ST.  FMRP associates with polyribosomes as an mRNP and the I304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell.  (1997) 1: 109-118

13. Brown V, Small K, Lakkis L, Feng Y, Gunter C, Wilkinson KD and Warren ST. Purified recombinant FMRP exhibits selective RNA-binding as an intrinsic property of the fragile X mental retardation protein. J. Biol. Chem.  (1998) 273, 11521-7

14.  New L, Zhao M, Li Y, Bassett WW, Feng Y, Ludig S, Padova FD, Gram H, and Han J. Cloning and characterization of RLPK, a novel RSK-related protein kinase. J. Biol. Chem.  (1999) 274, 1026-1032

15. Li Z, Zhang Y, Li D, and Feng Y.  Destabilization and mislocalization of MBP mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins. J. Neurosci. (2000) 20:4944-4953

16. Zhang Y and Feng Y  Distinct molecular mechanisms lead to diminished MBP and CNP in qkv dysmyelination J. Neurochem  (2001) 77:165-172

17. Li Z, Zhang Y, Ku L, Wilkinson KD, Warren ST, and Feng Y The fragile X mental retardation protein inhibits translation via interacting with mRNA Nucleic Acids Res  (2001) 29:  2276-2283

** Acknowledged by Thomson-ISI to be one of the most cited papers in the field of NEUROSCIENCE & BEHAVIOR. Will appear as part of the ESI Special Topics Fast Moving Front feature for March, 2005 (http://esi-topics.com).

18. Brown V, Jin P, Ceman S, Darnell JC, O'Donnell WT, Tenenbaum SA, Jin X, Feng Y, Wilkinson KD, Keene JD, Darnell RB, and Warren ST. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translation profiles in Fragile X syndrome. Cell  (2001) 107: 477-487

19. Keplinger  B L,  Guo X, Quine J, Feng Y, and Cavener DR. Complex organization of promoter and enhancer elements regulate the tissue- and developmental stage-specific expression of the Drosophila melanogaster Gld gene  Genetics  (2001), 157:699-716

20. Zhang Y, Lu Z, Ku L, Chen, Y, Wang H, and Feng Y Tyrosine-phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism  EMBO J (2003), 22: 1801-1810

21. Lu Z, Zhang Y, Ku L, Wang H, Ahmadian A, and Feng Y. The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system Nucleic Acids Res  (2003), 31:4616-4624

22. Wang H, Ku L, Osterhout DJ, Li W, Ahmadian A, Liang Z and Feng Y Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors Hum Mol Genet  (2004), 13: 79-89

23. Lu R, Wang H, Liang Z, Ku L, O'Donnell WT, Li W, Warren ST, and Feng Y  “The fragile X protein controls microtubule associated protein 1 translation and microtubule stability in brain neuron development” Proc. Natl. Acad. Sci. U.S.A. (2004), 101: 15201-15206

24. Zarnescu DC, Jin P, Betschinger J, Nakamoto M, Wang Y, Dockendorff TC, Feng Y, Jongens TA, Sisson JC, Knoblich JA, Warren ST and Moses K  “Fragile X protein functions with Lgl and the PAR complex in flies and mice" Dev. Cell  (2005), 8:43-52

25. Lu Z, Ku L, Chen Y, and Feng Y "Developmental abnormalities of myelin structural gene expression in the fyn knockout mice" J. Biol. Chem.  (2005), 280:389-395

26. Li W, Xia JT, Feng Y “ Microtubule stability and MAP1B upregulation control neuritogenesis in CAD cells” ACTA PHARMACOLOGICA SINICA (2006), 27:1119-1126

27. Wu C, Tian D, Feng Y, Polak P, Wie J, Sharp A, et al., “A Novel Fluorescent Probe that is Brain Permeable and Selectively Binds to Myelin” J Histochem Cytochem. (2006) 54:997-1004

28. Zhao LX, Ku L, Chen Y, LoPresti P, and Feng Y., “QKI binds MAP1B mRNA and enhances MAP1B expression during oligodendrocyte development” Mol. Biol  Cell (2006) 11:4179-4186

29.  Zhao LX, Tian D, Xia M, Macklin WB and Feng Y. “Rescuing qkv dysmyelination by a single isoform of the selective RNA-binding protein QKI”, J. Neurosci. (2006), 26:11278-11286

30. Tang X, Feng Y, and Ye K, “PIKE-A Tyrosine Phosphorylation by Fyn and Src Prevents its Apoptotic Cleavage, Promoting Cell Survival” Cell Death Differentiation (2007), 14:368-377

31. Chen Y., Tian D., Ku L., Osterhout D.J. and Feng Y. “The RNA-binding protein QKI is necessary and sufficient for promoting oligodendrocyte differentiation” J. Biol. Chem. (2007), 282:23553-60

32. Jin P, Duan R, Qurashi A, Oin Y, Toan D, Rosser TC, Liu H, Feng Y, Warren ST. Pur alpha Binds to rCGG Repeats and Modulates Repeat-Mediated Neurodegeneration in a Drosophila Model of Fragile X Tremor/Ataxia Syndrome.  Neuron. (2007), 55(4):556-64

33. Wang H, Dictenberg J, Ku L, Bassell GJ and Feng Y. Dynamic association of FMRP as an mRNP between microtubules and translating polyribosomes. Mol Biol Cell (2008), 19(1):105-114

34. Tang X, Jang SW, Okada M, Chan CB, Feng Y, Liu Y, Luo SW, Hong Y, Rama N, Xiong WC, Mehelen P, and Ye K.  “Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.” Nat Cell Biol. (2008) 10(6):698-706

35. An J, Gharam K, Liao G, Woo NH, Lau AG, Vanevski F, Torre ER, Jones KR, Feng Y, Lu B, and Xu B. “Distinct Role of Long 3'UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in the Apical Dendrites of Hippocampal Pyramidal Neurons” Cell  (2008) 134(1):175-187

36. Wu C,  Wei J,  Tian D, Feng Y,  Miller RH,  and Wang Y “Molecular Probes for Imaging Myelinated White Matter in CNS” (2008)  J. Med. Chem. 51(21):6682-8.

37. Gira AK, Kowalczyk A, Feng Y, Swerlick RA “Iron chelators and hypoxia mimetics inhibit IFNg mediated Jak-STAT signaling”  J Invest Dermatol. (2009) 129(3):723-9.

38. Irier HA, Shaw R, Lau AG, Feng Y, Dingledine RJ “Translational regulation of GluR2 mRNAs in rat hippocampus by alternative 3’ untranslated regions” (2009) J. Neurochem (109):584-594

39. Gu L, Zhu N., Zhang H, Durden DL, Feng Y, and Zhou M “Regulation of XIAP translation and induction by MDM2 following irradiation” (2009) CancerCell (15):363-375

40. Yang G, Fu H, Zhang J, Lu X, Yu F, Jin L, Bai L, Huang B, Shen L, Feng Y, Yao L, Lu Z. “RNA binding protein Quaking, a critical regulator of colon epithelial differentiation and a suppressor of colon cancer.” (2010)  Gastroenterology138(1):231-40

41. Sidell N, Feng Y, Hao L, Wu J, and Taylor RN “Translational regulation of Vascular Endothelial Growth Factor by retinoic acid in human endometrial stromal cells”  (2010) Mol Endocrinol 24(1):148-60

42. Ma L, Xiao Y, Huang H, Rao W,  Wang Q1FengY, Zhang K,  Song Q “Direct determination of molecular haplotypes by chromosome microdissection” (2010)  Nat Method  7(4):299-301

43. Lau AG, Iris H., Guo, J., Tian D, Ku L, Liu G, Xia M, Fritsch B, Zheng JQ, Dingledine RJ, Xu B, Lu B, and Feng Y “Distinct 3’UTRs play opposing roles in regulating BDNF translation” (2010) Proc. Natl. Acad. Sci. U.S.A. 107(36):15945-50

44. Lee SE, Simons SB, Heldt SA, Zhao M, Schroeder JP, Vellano CP, Cowan DP, Ramineni S, Yates CK, Feng Y, Smith Y, Sweatt JD, Weinshenker D, Ressler KJ, Dudek SM, Hepler JR. “RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. (2010) Proc Natl Acad Sci U S A. 107(39):16994-8

45. Zhao L, Mandler M, Yi H and Feng YQuaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein.” (2010)  Proc Natl Acad Sci U S A. 107(44):19061-6

46. Pak C, Garshasbi M, Kharizi K, Gross C, Apponi L, Noto J, Kelly S, Leung S, Tzschach A, Behjati F, Abedini S, Mohseni M, Jensen L, Hu H, Huang B, Stahley S, Liu G, Williams K,  Burdick S, Feng Y, Sanyal S, Bassell G, Ropers H, Najmabadi H, Corbett A,  Moberg K(corr-auth), Kuss A (2011)“Mutation of the Conserved Polyadenosine RNA Binding Protein, ZC3H14/dNab2, Impairs Neural Function in Drosophila and Humans” Proc Natl Acad Sci U S A 108(30):12390-5

47. Tyler W, Jain M, Cifelli S, Li Q, Ku L, FengY, Li H, and Wood T (2011) “Proteomic Identification of Novel Targets Regulated by the Mammalian Target of Rapamycin Pathway during Oligodendrocyte Differentiation”  Glia  59(11):1754-69

48. Zhu H, Zhao L (co-first author), Wang E, Dimova N, Liu G, Feng Y (co-corresponding) and Cambi F. (2012) “The QKI-PLP pathway controls SIRT2 abundance in CNS myelin.” Glia  60(1):69-82

49. Seyfried N, Gozal Y, Donovan L, Herskowitz J, Dammer E, Ku L, Chan J, Duong D, Rees H, Cooper D, Glass J, Gearing M, Tansey M, Lah J, Feng Y, Levey A and Peng J (2012) “PTB-associated splicing factor insolubility and cytoplasmic distribution is observed among oligodendrocytes in neurodegenerative disease” J Proteome Res 11(5):2721-38

50. Allen M, Bird C, Feng W, Liu G, Li W, Perrone-Bizzozero NI, and Feng Y (2013) “HuD Promotes BDNF Expression in Brain Neurons via Selective Stabilization of the BDNF Long 3’UTR mRNA” PLoS One 8(1):e55718

51. Bankston AN, Li W, Zhang H, Ku L, Liu G, Papa F, Zhao L, Bibb JA, Cambi F, Tiwari-Woodruff SK, Feng Y. (2013) “P39, the primary activator for cyclin-dependent kinase 5 (Cdk5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair.J Biol Chem. 288(25):18047-57

52.  Dammer EB, Duong DM, Diner I, Gearing M, FengY, Lah JJ, Levey AI, Seyfried NT (2013) “Capturing a Neuron-specific Nuclear Proteome from Human Brain” J Proteome Res 12(7):3193-206

53. Chan CB, Liu X, Zhao L, Liu G, Lee CW, Feng Y(co-corresponding), Ye K. (2014)  “PIKE is essential for oligodendroglia development and CNS myelination”. Proc Natl Acad Sci U S A. 111(5):1993-8

54. Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Li W, Feng Y, Warren ST, Jin P, Sun Q, and Chen D (2014) “Coordination of engineered factors with TET1/2 promotes early stage epigenetic modification during somatic cell reprogramming” Stem Cell Reports. 2(3):253-61.

55. Charlse B Wright, Micah A. Chrenek, Wei Feng, Shannon E. Getz, Todd Duncan, Machelle T. Pardue, Yue Feng, T. Michael Redmond, Jeffrey H. Boatright, John M. Nickerson (2014) “The Rpe65rd12 allele exerts a semidominant effecton on vision in mice” Invest Ophthalmol Vis Sci. 55(4):2500-15.

56. Mandler MD, Ku L, and FengY (2014) “A Cytoplasmic Quaking I Isoform Regulates the hnRNP F/H-dependent Alternative Splicing Pathway in Myelinating Glia” Nucleic Acids Res.

57. Xu Y, Gao XD, Lee JH, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Gius D, Siziopikou KP, Peng J, Xiao X, Cheng C. (2014) “Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing”. Genes Dev 28(11):1191-203. PMID: 24840202

58. Wigington CP, Jung J, Rye EA, Belauret SL, Philpot AM, Feng Y, Santangelo PJ, Corbett AH. “Post-transcriptional Regulation of Programmed Cell Death 4 (PDCD4) mRNA by the RNA Binding Proteins Human Antigen R (HuR) and T-cell Intracellular Antigen 1 (TIA1).” J Biol Chem. 2015  290(6):3468-87

59. Huang, B, Wei, WJ, Wang, GH, Geartig, MA, Feng, Y, Wang, W, Li, X-J and Li, SH. (2015) Mutant huntingtin down-regulates Myelin Regulatory Factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron 85(6):1212-26

60. Tan X., Chen Y., Li J., Li X., Mioa Z., Zhu J., Ge W., Feng Y. (co-corresponding), Xu X (2015) “The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats” Neuroscience 290:552-60

61. Chen X, zhang W, Li T, Guo Y,Tian Y, Liu S, Wang W, Shen H, Feng Y (co-corresponding), Xiao L (2015) “Impairment of oligodendroglia maturation leads to aberrantly increased cortical glutamate and anxiety-like behaviors in juvenile mice” Frontiers Cell Neurosci 9:467. doi: 10.3389/fncel.2015.00467

62. Myers KR, Liu G, Feng Y, Zheng JQ. (2016) “Oligodendroglial defects during quakingviable cerebellar development.” Dev Neurobiol 76:972-82

63. Williams KR, McAninch DS, Stefanovic S, Xing L, Allen M, Li W, Feng Y, Mihailescu MR, and Bassell GJ (2016) “hnRNP-Q1 represses nascent axon growth in cortical neurons by inhibiting Gap-43 mRNA translation” Mol Bio Cell  27: 518-534

64. Suiko T, Kobayashi K, Aono K, Kawashima T, Inoue K, Ku L, Feng Y, Koike C (2016) “Expression of Quaking RNA-binding protein in the adult and developing mouse retina” PLoSOne e0156033

65. Li W, Allen ME, Rui Y, Ku L, Liu G, Bankston AN, Zheng JQ, Feng Y (2016) “p39 is responsible for increasing Cdk5 activity during postnatal neuron differentiation and governs neuronal network formation and epileptic responses”  J Neurosci 36(44):11283-11294.

66. Sethna F, Feng W, Ding Q,  Robison AJ,  Feng Y, Wang H (2017) “Enhanced expression of ADCY1 underlies aberrant neuronal signaling and behavior in a syndromic autism model” Nat Comm (accepted)

Imbert, G., Feng Y, Nelson DL, Warren ST and Mandel J-L.  FMR1 and mutations in fragile X syndrome: molecular biology, biochemistry and genetics. Genetic Instabilities and Hereditary Neurological Diseases. (R.D. Wells and S. T. Warren eds.), pp.27-53, Academic Press, San Diego, CA, 1998

Feng Y and Bankston A The SATR member quaking (QKI) and cell signaling.  Post-Transcriptional Regulation by STAR Proteins: Control of RNA Metabolism in Development and Disease. (K. Artzt and T. Volt eds.)  pp25-36, Landes Bioscience, 2010

Editorial comments

1.  Feng Y.  Fragile X mental retardation: misregulation of protein synthesis in the developing brain? Microscopy Res.Tech. (2002), 57:145-147

Invited Reviewer Articles

1.  Feng Y. Molecular mechanisms of fragile X mental retardation: functional perspectives of protein synthesis in learning and memory J Peking University (Health Sciences) (2002)

2. Feng Y, “Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction" Neurochem. Res. (2008) 33(10):1940-9.

3.  Bockbrader K and Feng Y “Essential function, sophisticated regulation and pathological impact of the selective RNA-binding protein QKI in CNS myelin development" Future Neurology (2008) 3(6):655-668

4. Feng W and Feng Y (2011) “microRNAs in neural cell development and diseases” (2011) SCIENCE CHINA: Life Sciences 54 (2): 1103–1112

5.  Bankston AN, Mandler MD and Feng Y (2013) “Oligodendroglia and Neurotrophic Factors in Neurodegeneration” Neurosci Bulletin 29(2):216-28

6. Huang N, Niu J,Feng Y, Xiao L. (2015) “Oligodendroglial Development: New Roles for Chromatin Accessibility. Neuroscientist. 2015 Jan 6